George Minot, 2 December 1885

George Hathorn Smith 1885-1952 *

The Inquisitive Physician. The Life and Times of George Francis Minot

This current edition of the annual review of new developments in the field of "stress" follows the pattern of the previous ones. The first hundred pages are occupied by a summary of the concept of "stress" as developed by Selye and his colleagues. A great deal of this repeats material from previous editions, some of it word for word. A series of nine review articles is then inserted. These incl...

December (Final Notebook.2)

Feeding regulation involves multiple peripheral and brain mechanisms (12). Chemical signaling is a pivotal mechanism. One class of endogenous feeding-regulatory substances is represented by cytokines. In this article, various issues of feeding inhibition by cytokines are discussed, including behavioral, cellular, and molecular mechanisms. The description will focus on data obtained with interle...

December (Final Notebook.2)

Artiodactyls employ selective brain cooling (SBC) regularly during experimental hyperthermia. In free-ranging antelopes, however, SBC often was present when body temperature was low but absent when brain temperature was near 42°C. The primary effect of SBC is to adjust the activity of the heat loss mechanisms to the magnitude of the heat stress rather than to the protection of the brain from th...

December (Final Notebook.2)

“reflex circuits.” Each neural circuit contains an afferent neuron that carries electrical activity from the periphery to a center of integration, either a ganglion or a specialized region of the brain. After afferent signals are processed, information flows back to the periphery via motoneurons to modify behavior. Thus afferent neurons were thought to be the sensors of the digestive state. Sin...